| Cheung Hoi Yu | | 18-Oct-25 | INED, MbAC, MbCC, Mb InvestigationC | | Dr. Yu wishes to devote more time to his other commitments. |
| Dai Xiaochang | 19-Jul-22 | 21-Oct-24 | ED | | Dr. Dai wishes to devote more time to his other commitments. |
| 25-Jan-21 | 19-Jul-22 | NED | | Dai has been re-designated from a non-executive Director to an executive Director |
| Dr. Francois Lebel | | 31-May-24 | Chief Medical Officer | | To devote more time to his other commitments |
| Dr. Xiaochang Dai | | 21-Oct-24 | MbCC | | Dr. Dai wishes to devote more time to his other commitments. |
| 17-May-24 | Chief Strategy Officer | | Due to his personal reasons |
| Dr. Yang Lu | | 05-Nov-24 | CEO, ED | | Re-designation as Chief Scientific Officer and from an executive Director to a non-executive Director. Dr. Lu will provide support to Dr. Poon and facilitate a smooth transition. |
| Dr. Yang Lu (Alias Patrick Lu) | | 23-Apr-25 | Honorary Scientific Advisor of the Group, All positions of Sirnaomics Biopharmaceuticals (Guangzhou) Co., Ltd., All positions of Sirnaomics Biopharmaceuticals (Suzhou) Co., Ltd., All positions of Sirnaomics, Inc. | | The Cessation allows the new management team room to focus its efforts on stringent internal control measures and on regulatory compliance. |
| 05-Feb-25 | NED | | Dr. Lu wishes to devote more time to his other commitments. |
| 20-Dec-24 | Pres | | Dr. Lu will focus his efforts on business strategies in the US for the Group and has requested to retire from his positions. |
| Evans David Mark | 12-Jul-21 | 20-Jun-24 | ED | | AGM ordinary resolutions regarding, re-election was not passed. Dr. Evans will remain as the Head of Drug Discovery and Collaboration of the Group |
| Ghias Mike M | 25-Jan-21 | 12-Jul-21 | NED | | |
| Hua Fengmao | 20-Dec-21 | 20-Jun-24 | INED | | AGM ordinary resolutions regarding, re-election was not passed. |
| Huang Mincong | 25-Jan-21 | 01-Jan-25 | NED | | Mr. Huang wishes to devote more time to his other commitments. |
| Lai Jiajun | 25-Jan-21 | 31-Aug-22 | NED | | Mr. Lai wishes to devote more time to his other commitments. |
| Law Shing Yvonne Mo Han | 20-Dec-21 | 01-Jan-25 | INED | | |
| Leung Leo Ting Cheung | | 30-Nov-24 | CoSec | | |
| Li Yunchun | 25-Jan-21 | 12-Jul-21 | NED | | |
| Liu Da | 25-Jan-21 | 30-Sep-22 | NED | | Mr. Liu wishes to devote more time to his other commitments |
| Lu Patrick Yang | 20-Dec-24 | 05-Feb-25 | Fdr, NED | | |
| 05-Nov-24 | 20-Dec-24 | Ch, Fdr, NED | | |
| 15-Oct-20 | 05-Nov-24 | Ch, CEO, Fdr, Pres | | |
| Molyneaux Michael V | 25-Jan-21 | 30-Nov-23 | ED | | Dr. Molyneaux wishes to devote more time to his other commitments |
| Monin Ung | | 01-Dec-25 | MbAC | | Ms. Ung wishes to devote more time to decentralized life science and to expanding her law offices in China. Ms. Ung will remain as an advisor to the Company after her resignation. |
| Mr. Fengmao Hua | | 20-Jun-24 | MbAC | | AGM ordinary resolutions regarding, re-election was not passed. |
| Mr. Jiankang Zhang | | 21-Jun-25 | MbCC | | Mr. Zhang wishes to devote more time to his family and other commitments. |
| Mr. Leung Ting Cheung | | 30-Nov-24 | CoSec | | Resigned. Mr. Leung confirmed that he had no disagreement with the Board and there were no other matters relating to his resignation that need to be brought to the attention of the shareholders of the Company or The Stock Exchange of Hong Kong Limited. |
| Mr. Mincong Huang | | 01-Jan-25 | MbAC | | Mr. Huang wishes to devote more time to his other commitments. |
| Mr. Yip Wing Kei (Alias Nigel Yip) | | 31-May-24 | CFO | | To devote more time to his other commitments |
| Ms. Shing Mo Han, Yvonne | | 01-Jan-25 | INED | | Ms. Shing wishes to devote more time to her other commitments. |
| Ouyang Yunlong | 03-Jul-25 | 05-Jun-26 | NED | | Mr. Ouyang wishes to devote more time to his other commitments. |
| 01-Sep-25 | 05-Jun-26 | MbAC, MbCC | | Mr. Ouyang wishes to devote more time to his other commitments. |
| Poon Hung Fai | 05-Nov-24 | | CEO | | |
| 15-Oct-24 | 05-Nov-24 | ED | | |
| Ung Monin | 20-Dec-24 | | Ch | | |
| 20-Dec-24 | 01-Dec-25 | INED | | Ms. Ung wishes to devote more time to decentralized life science and to expanding her law offices in China. Ms. Ung will remain as an advisor to the Company after her resignation. |
| 20-Dec-21 | 20-Dec-24 | INED | | |
| Wang Edward Yongxiang | 10-May-24 | 20-Jun-24 | ED | | AGM ordinary resolutions regarding, re-election was not passed. Dr. Wang will remain as the Chief Production Officer of the Group. |
| Wong Eugene Yu Shan | 01-Sep-25 | | MbCC, Mb InvestigationC | | |
| 17-Feb-25 | | INED | | |
| Yin Huijun | 05-Jun-26 | | MbAC, MbCC | | |
| 01-Sep-25 | | NED | | |
| Yip Nigel Wing Kei | 15-Nov-22 | 31-May-24 | CFO | | |
| Yu Albert Cheung Hoi | 20-Dec-21 | | INED | | |
| Yuen Yun Ting | 30-Nov-24 | | CoSec | | |
| Yun Zhang, Monica | | 31-Aug-23 | J-CoSec | | No reasons provided. |
| Zhang Jiankang | 12-Jul-21 | 21-Jun-25 | NED | | Mr. Zhang wishes to devote more time to his family and other commitments. |
| Zhang Monica Yun | | 31-Aug-23 | CoSec | | |
